Synthesis of 2-Styryl-3, 6,8-Trisubstituted Quinazolin-4(3H)-ones as Anti-inflammatory Agents

Sixteen new quinazolinone derivatives have been synthesiled by the reaction of 2­styryl-6, 8-disubstituted benzoxazjn.4-o~ with two different aromatic ambles (p-morpholino lIDiline and 2-aminopyridjne) or with two different hydruiclea (viz. iJonicotink: acid hydrazide and 2,4­dinitrophenyl acetic acid hydrazide) in pyridine. The intermediate 2-styryl 6.lktiIubstituted benzo. xin-4-ones, were prepared by the reaction of cinnlmQyl chloride and 6.8-cliIUbstituted anthranlic acid in dry pyridine. Some of the synthesiled title compounds have been found to poaeIS lipificant anti-inflammatory activity against carrageenin-induced in1Iammation. An attempt hu also been made to establish a definite structure activity relationship. Further, in addition, the compounds were found to be mild central nervous system depreuaats and were quite non toxic. The structures of the un­known compounds were confirmed by elemental and spectral (LIt. cl P.M.L) analysis.

C SINGH ,V S MISRA ,R AGARWAL ,K C CHAUDHARY ,