3-Nitrobenzylidene-p-isopropylacetophenone (1a) reacts with hydrogen peroxide to give the oxirane derivative (2). The cleavage of the strained oxirane ring with oxygen nucleophiles e.g. OH or nitrogen nucleohpiles e.g.hydrazine hydrate or hydroxylamine has been described. The reaction of (1) with ethylcyanoacetate in the presence of ammonium acetate leads to the formation of nicotinonitrile derivative (7) toward wome electrophiles e.g. ethylchloroacetate or dimethyl sulphate or some nucleophiles e.g. phosphorous oxychloride has been investigated.
M A SAYED ,N MOSTAFA ,M EL-MOBAYED ,M A EL-HASHASH ,A F EL-FARARGY ,
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