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Continuous Online Flow Analysis of the Chromium (III) Ion in Drugs using Five Snow White LEDs as Radiation Sources Arranged in a Single Row Matrix Cell Photometer

A new spectrophotometric flow injection analysis method has been successfully developed to measure chromium (III) ion levels. This approach relies on the oxidation of the chromium (III) ion by hydrogen peroxide in a basic environment, leading to the formation of the chromate ion. This ion subsequently reacts with 1,5-diphenylcarbazide in an acidic solution, resulting in a striking blue-violet complex. Under optimal conditions, the method demonstrates a linear response within the range of 0.05 to 15 mmol.L-1, achieving a high correlation coefficient (r) of 0.9912. The detection limit is impress..read more


Marwah A. Kadhim Al-banaa, Nawras Majid Hassouni, Turkey, Nagham Shakir and Hussein Fares Abd-Alrazack

DFT Quantum Chemical Calculations and Statistical Analysis of 2-Amino-6-arylsulfonylbenzonitrile Derivatives and their Electrical Properties

Quantum chemical calculations were performed for gas and water phases using the DFT/B3LYP/6-311G(d,p) basis set to determine some molecular properties of 2-amino-6-arylsulfonylbenzonitrile derivatives (1-61). The quantum chemical properties of these compounds such as EHOMO (highest occupied molecular orbital energy), ELUMO (lowest unoccupied molecular orbital energy), HOMO-LUMO energy gap (∆E), ionization potential (I), chemical hardness (η) and softness (σ), etc. values were calculated and the results were discussed. This research aims to construct the relationship between HIV-reverse transcr..read more


M. Izzettin Yilmazer, Murat Saracoglu, Murat Alper Basaran, Hakan Sezgin Sayiner and Fatma Kandemirli

Covalent Immobilization of Glutathione-S-Transferase onto Magnetic Iron Nanoparticles via Epichlorohydrin Spacer Arm

This study examined the synthesis of Fe3O4 magnetic nanoparticles (MNPs) and the covalent immobilization of glutathione-S-transferase (GSTs) onto these nanoparticles using an epichlorohydrin (ECH) spacer arm, as well as the optimal reaction conditions for both free and immobilized enzymes and the reusability of the immobilized enzyme. The optimal pH values for free and immobilized enzymes were established as 7.0 and 6.0, respectively. It was found that the ideal temperature for both free and immobilized enzymes was 37 and 40 °C, respectively. Under the optimum conditions, the values of Vmax fo..read more


M. Kemal Caglar, Nuri Gulesci, Ramazan Bilgin and Guzide Yucebilgic

Rapid, Simple, and Cost-Effective Analytical Method Validation of the Mixture of Lidocaine and Methylparaben Combination for Assay Determination

Lidocaine, a versatile analgesic, serves as a local anesthetic for topical dermal applications and as an agent to mitigate discomfort associated with chemotherapy in cancer patients. It is also utilized for postoperative pain management. Given its diverse applications, it is essential to investigate analytical and detection methods for lidocaine and its associated compounds, such as methylparaben. The present study introduces a simple and validated procedure for performing such analyses. The chromatographic system employed in this study comprised a GL Science Inc. Intersil ODS-3 column (150 mm..read more


Bandar R. Alsehli, Basima A.A. Saleem, Mahmoud Abdulnasser, and Mostafa F. Al-Hakkani

Oilseeds from Arid Algeria:Fatty Acid Profiles, Physicochemical Properties, and Food Security Implications

: Food security in arid regions is challenged by climate change and reliance on imported goods, making the valorization of local, drought-tolerant crops a key strategy for sustainability; this study therefore aimed to characterize the physicochemical properties and fatty acid profiles of oils from five local oilseeds—peanut, safflower, rapeseed, soybean, and sunflower—cultivated in the arid El-Oued region of Algeria. Oils were obtained using the Soxhlet extraction method and analyzed for refractive index, acid value, and saponification value according to ISO and AOCS standards, while fatty aci..read more


Ahmed Allali, Smail Acila, Intissar Oucif Khaled, Samiha Ben Nacer Nadjat Gedaeir Ahmed, Hana Djaballah

Ag Nanoparticle Green Synthesis using Litchi chinensis Peels Extract: Mutagenicity, Cytotoxicity, Antimicrobial and Antioxidant Activities Evaluation

In view of the promising therapeutic potential of AgNPs, in the present study, the cytotoxicity of AgNPs was evaluated against HepG2, which were prepared using Litchi chinensis peels (LCP) extract. The mutagenicity, antimicrobial and antioxidant activities were also evaluated. The AgNPs showed favorable antioxidant activity, i.e., total phenolic contents (TPC) (48.46 mg GAE/g DW), total flavonoid contents (TFC) (35.83 mg CE/g DW) and free radical scavenging (84.93% inhibition). The antibacterial activity was assessed against E. coli, B. subtilis, P. multocida, and S. aureus bacterial strains, ..read more


Mazhar Abbas, Aqsa Mumtaz, Norah Alwadai, Munawar Iqbal, Arif Nazir, Ismat Bibi, Abid Ali, Naveed Ahmad and Maryam Al Huwayz

Micro Wave-Assisted Fast Extraction of Oil from Thrombolytic Agent Native Earthworm (Lampito mauritii, Kinberg) their GC-MS Quantification of the Fatty Acids and Evaluation of Lipids by ATR FTIR Spectroscopy

Fatty acids methyl esters (FAMES) were synthesised utilizing the iupac standard, 1979 method 2.301 and their significance on the basis of nutritional research purpose. The earthworms were microwave extracted, then analysed for fatty acids composition according to aoac method. Fourier transform infrared spectroscopy used to identify the distinctive peaks of the fatty acid spectrum, whereas gas-chromatography combined with mass spectroscopy was used to evaluate the fatty acid composition of earthworm (Lampito mauritii, Kinberg). The current investigation identified two unsaturated fatty acids (C..read more


Nighat Sultana, Zakia Khatoon, Dhani Bux Mashori, Adel Zia Siddiqui Kiran Rafiq, Aftab Ahmed Kandhro

Evaluation of Antioxidant, Anti-urease, Lipoxygenase, and Butyrylcholinesterase Inhibition Activities of Isatin Thiazole Derivatives Using Nano Formulations

This study investigates the enzyme inhibition and antioxidant activities of various nanoparticles loaded with three isatin thiazole derivatives. For drug encapsulation, two different nanoparticle systems were examined: polysaccharide-based nanoparticles, including alginate-chitosan nanoparticles (ACN) and gum-chitosan nanoparticles (GCN), and polymer-lipid hybrid nanoparticles based on the lipid soya lecithin in combination with either sodium alginate (PLHN-A) or gum acacia (PLHN-G). The biological activities of the drug-loaded nanoparticles were evaluated against key targets, including antiox..read more


Khadim Mohi Uddin, Najia Mansoor, Syed Imran Ali, Mohsin Ali, Mansoor Ahmed, Mehwish Solangi, Shazia Haider, and Khalid Mohammed Khan

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