Sixteen new title styryl quinazolinones have been synthesized by knoevenagel condensation of 2-methyl-3-(p-morpholinophenyl)6,8-disubstituted-quinazolin-4(3H)-ones with 2-aryl-indol-3-aldehydes in the presence of gl. AcOH. The intermediates, 2-methyl-3-(p-morpholinophenyl) 6,8-disubstituted quinazolin-4(3H)-ones, were prepared by the direct fusion of 6,8-disubstituted-acetyl anthranils with p-morpholinoaniline. Some of the title compounds have shown significant inhibition against carrageenin induced oedema. A definite SAR has also been established. In addition, the compounds were found to be psychotropic (stimulants and depressants) and quite nontoxic. The structures of the unknown compounds were confirmed by elemental and spectral (IR & PMR) analysis.
VINAY S MISRA ,(MRS.) CHAPLA AGARWAL CHARANJETT SINGH ,RAJESH AGARWAL ,
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